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7th Annual Course on the BBB in CNS Drug Development 2016 (Leiden, The Netherlands)
October 5, 2016 - October 7, 2016
Following the previously successful ones, the 7th Annual Course on the BBB in CNS Drug Development is organized in 2016!
This course addresses the latest insights on role and functions of the Blood-Brain Barrier (BBB) and intra-brain distribution in research concerning drug development regarding drugs aimed for a target within the CNS or drugs aimed to stay outside of the CNS, and will address also CNS drug delivery and CNS diseases. It provides in depth insight in the complex function of the BBB with regard to transport kinetics in health and disease.
There is a high unmet medical need in the treatment of CNS diseases and this problem is getting worse as the number of people suffering from CNS diseases is growing. This implies that there is a huge market for new CNS drugs. However, the development of new CNS drugs is notoriously difficult. For a proper CNS effect the drug should have the ability to cross the BBB and then to reach the relevant target site within the CNS by adequate intra-brain distribution. Also drugs that are aimed to have a peripheral action, but may bear risks for CNS side effects can be better optimized with more knowledge on BBB transport and CNS side effect site distribution.
Thus, knowledge on the physiological and pharmacokinetic aspects of drug delivery to the brain and distribution within the brain compartments is of utmost importance for all drug delivery scientists. Also medicinal chemists need further knowledge on pharmacokinetic principles of CNS distribution to be guided in finding more optimal molecules for CNS action or for the avoidance of CNS side effects.
Who should attend?
This course will be of benefit to researchers from Academia, Big and Small Pharma Industries, Regulatory Agencies and Contract Research Organizations with a need for better understanding of the BBB and factors that determine CNS target site distribution of drugs. A general understanding of physiology and minimal knowledge of differential equations is expected (some information can be provided upon request).
After having taken this course, the participants will
- have in-depth insight into mechanisms that contribute to BBB transport and intra-brain distribution, with special emphasis on drug delivery and active transport mechanisms
- know about the driving forces that determine whether or not a CNS drug will be at the right place, at the right time and at the right concentration
- be able to compare and choose between different methods for studying parameters that can be used to understand or predict BBB transport and CNS distribution
Wednesday Oct 5th 2016
Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles
|09.00 – 09.30||Welcome and Introduction|
|09.30 – 10.00||BBB Morphology, Anatomy, Physiology and Function|
|10.00 – 10.30||Coffee and Tea|
|10.30 – 11.30||BBB Transport Modes|
|11.30 – 12.30||General Pharmacokinetic (PK) Principles|
|12.30 – 14.00||Lunch|
|14.00 – 14.45||Approaches to Overcome Problems in CNS Drug Delivery|
|14.45 – 15.30||Factors in CNS Drug Effects|
|15.30 – 16.00||Coffee and Tea|
|16.00 – 16.45||Sources of variability in CNS Drug Distribution|
|16.45 – 17.30||Discussions BBB Research Issues|
|18.00 – 20.00||Dinner|
Thursday Oct 6th 2016
Principles and Methods for Investigating BBB Transport
|09.00 – 10.00||BBB transport: Rate and Extent. Impact on Brain vs Plasma PK|
|10.00 – 10.30||Coffee and Tea|
|10.30 – 11.00||In vitro Methods: Cell systems|
|11.00 – 11.30||In Situ Methods|
|11.30 – 12.30||In vitro Methods: Brain slice and Homogenate|
|12.30 – 13.30||Lunch|
|13.30 – 14.30||In vivo Monitoring Methods: CSF & Microdialysis|
|14.30 – 15.30||In vivo Monitoring Methods: PET|
|15.30 – 16.00||Coffee and tea|
|16.00 – 17.00||Factors that influence unbound brain pharmacokinetics|
|17.00 – 17.30||Discussions|
|18.00 – 21.30||Dinner|
Friday Oct 7th 2016
Pharmacokinetics of CNS Drug Delivery
|09.00 – 10.00||PKPD relationships of CNS active drugs|
|10.00 – 10.30||Coffee and Tea|
|10.30 – 11.00||PKPD relationships of CNS active drugs (cont.)|
|11.00 – 12.30||Hands-on comp Exercises on Relationships between Plasma and Brain PK|
|12.30 – 13.30||Lunch|
|13.30 – 14.30||What Parameters to Use in CNS Drug Development?|
|14.30 – 15.00||Discussion, Perspectives, and Conclusions|
|15.00 – 15.15||Course Evaluation, Certificates and final comments|
Evaluations from the 2015 course in Uppsala
On a scale from 1 – 10, where 10 is top evaluation, the course received the following scores in 2014:
“I found the course to be very valuable for my present work”: 9.0
“I would very much like to recommend this course to colleagues”: 9.3
The course will take place at Hotel Leiden, Haagsche Schouwweg 14, 2332 KG Leiden Tel +31 (0)71 5 731 731, Fax +31 (0)71 5 731 710
Van der Valk Hotel Leiden is a four star hotel located on the A44, just outside the city center of Leiden. The flowing water of the Old Rhine at her side, makes Van der Valk Hotel Leiden a very special location. It is easily accessible by car the A44 highway (The Hague-Schiphol-Amsterdam) and by public transport. By bus, it takes only ~5 min from the Central Station to the Hotel (line 43).
The course fee includes course attendance, course material, lunches, dinners, coffee/tea at start and during breaks. It does not include accommodation.
Payment completed before July 1st 2016:
|PhD students*||€ 1395,- (excl. VAT)|
|Academic||€ 1595,- (excl. VAT)|
|Business||€ 1795,- (excl. VAT)|
Payment completed before September 1st 2016:
|PhD students*||€ 1695,- (excl. VAT)|
|Academic||€ 1895,- (excl. VAT)|
|Business||€ 2095,- (excl. VAT)|
VAT is currently 21%.
*PhD students should accompany this form by a letter of their supervisor to ensure the status of PhD student.
Please register via the digital registration form at:
A specified invoice can be made upon request. Registration is complete upon receiving the payment. A confirmation of payment and therewith registration will be sent by email.
ING Bank (PO Box 2338, 3000 CH Rotterdam, The Netherlands)
IBAN Account NL47 INGB 0651 4673 73
SbN Doormanlaan 8
2243 AL Wassenaar
VAT: NL 8159.63.567.B.01
C. of C. no: 272 830 74
In case of cancellation before July 1st 2016 payment will be restituted (-10% administration costs).
In case of cancellation after July 1st 2016 there will be no restitution, but the participant may be exchanged for another participant.
The course is a coproduction of In Focus and Udenaes Consulting:
Elizabeth de Lange is Head of the Target Site Equilibration group of the Division of Pharmacology at the LACDR. She obtained her PhD on The Use of Microdialysis to Study the BBB Transport Characteristics of Drugs. Her ultimate aim is to aid in the prediction of the dose-response relationship of CNS drugs in the clinical setting, on the basis of preclinical data (translational research). Her research involves the identification and characterization of the rate and extent of key factors in the dose-response relationship of CNS drugs in health and CNS disorders. Dr de Lange’s current research involves the use of advanced preclinical research (e.g. including microdialysis, EEG monitoring, PET scanning) and advanced pharmacometrics (Systems Pharmacology).
Dr Ede Lange is a member of the Editorial Board of Fluids and Barriers of the Central Nervous System (FBCNS) . She co-founded and (co-) chaired several of the International Symposia on Microdialysis in Drug R&D. She has been Chair of the Organizing Committee of the 9th International Cerebrovascular Biology (CVB), Conference (2011, Leiden, The Netherlands). Furthermore, she was the 2014 Chair of the Annual Meeting Programming Committee of the American Association of Pharmaceutical Scientists (AAPS), after many other functions within this organization. She is an AAPS Fellow since 2013. She is a frequently invited lecturer. Her company In Focus provides courses, training and advice on microdialysis, pharmacokinetics, BBB transport, and CNS target site distribution and effects, and systems pharmacology (email@example.com)
Margareta Hammarlund-Udenaes is a Professor in Pharmacokinetics and Pharmacodynamics at Uppsala University and head of the Translational PKPD Group. Her research is focused at studying pharmacokinetic aspects of BBB transport of drugs in relation to CNS effects, which has led to the development of new concepts within the BBB transport area, focusing on unbound drug relationships. The concepts make it possible to study the BBB contribution to drug transport to the CNS. A method frequently used is microdialysis, but also PET and other techniques are utilized. Her research group has also optimized in vitro methods for more rapid screening of BBB transport properties in drug discovery.
Dr Hammarlund-Udenaes is an Associate Editor of Pharmaceutical Research and a member of the Editorial Advisory Board of Journal of Pharmaceutical Sciences and Fluids and Barriers of the Central Nervous System (FBCNS). She became an AAPS Fellow in 2005 and is a frequent lecturer at conferences and in drug industry within the BBB transport – pharmacokinetics area. She co-founded and has co-chaired several of the International Symposia on Microdialysis in Drug Research and Development together with Dr de Lange. She is the Chair of the Gordon Conference on Barriers of the CNS in 2014. Her company Udenaes Consulting (firstname.lastname@example.org) gives advice to drug industry in PKPD and BBB transport issues.
Van der Valk Hotel Leiden
Haagsche Schouweg 14
2332 KG Leiden
Het Haagsche Schouw is combined with a very modern 4 star Hotel. Comfortable and tastefull decorated rooms furnished with one double bed.
The rooms have a spacious bathroom with bubble bath and separate shower. All rooms are equipped with a flatscreen television with remote control, telephone, safe, writing desk with a comfortable chair, wireless internet (WiFi) and a small refridgerator.
For information on other hotels (few examples below) please visit Booking.com
Golden Tulip Leiden Centre
Schipholweg 3, 2316 XB, Leiden, Nederland
Holiday Inn Leiden
Haagse Schouwweg 10, 2332 KG Leiden, Nederland
Tulip Inn Leiden Centre
Schipholweg 3, 2316 XB Leiden, Nederland
Marienpoel Hotel Leiden
Marienpoelstraat 1A, 2334 CW Leiden, Nederland