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10th Course on the BBB in CNS Drug Development

October 2 - October 4


General


 

Update August 8th 2019:

Dear colleague,

We have reached the maximum number of participants for this course.
If you are interested you can be placed on a waiting list.
( We are investigating if there is a possibility to change to another location with higher capacity).
All the best,

Course leaders


Following the previously successful ones, the 10th Annual Course on the BBB in CNS Drug Development is organized in 2019!

Aim

This course addresses the latest insights on role and functions of the Blood-Brain Barrier (BBB) and intra-brain distribution in research concerning drug development regarding drugs aimed for a target within the CNS or drugs aimed to stay outside of the CNS, and will address also CNS drug delivery and CNS diseases. It provides in depth insight in the complex function of the BBB with regard to transport kinetics in health and disease.

Background

There is a high unmet medical need in the treatment of CNS diseases and this problem is getting worse as the number of people suffering from CNS diseases is growing. This implies that there is a huge market for new CNS drugs. However, the development of new CNS drugs is notoriously difficult. For a proper CNS effect the drug should have the ability to cross the BBB and then to reach the relevant target site within the CNS by adequate intra-brain distribution. Also drugs that are aimed to have a peripheral action, but may bear risks for CNS side effects can be better optimized with more knowledge on BBB transport and CNS side effect site distribution.
Thus, knowledge on the physiological and pharmacokinetic aspects of drug delivery to the brain and distribution within the brain compartments is of utmost importance for all drug delivery scientists.

Thus, knowledge on the physiological and pharmacokinetic aspects of drug delivery to the brain and distribution within the brain compartments is of utmost importance for all drug delivery scientists.

Who should attend?

This course will be of benefit to researchers from Academia, Big and Small Pharma Industries, Regulatory Agencies and Contract Research Organizations with a need for better understanding of the BBB and factors that determine CNS target site distribution of drugs. Also medicinal chemists who need further knowledge on pharmacokinetic principles of CNS distribution can be guided in finding more optimal molecules for CNS action or for the avoidance of CNS side effects. A general understanding of physiology and minimal knowledge of differential equations is expected (some information can be provided upon request).

Learning Objectives

After having taken this course, the participants will

  • have in-depth insight into the mechanisms governing BBB transport and intra-brain distribution, with special emphasis on drug delivery and active transport mechanisms
  • know about the driving forces that determine whether or not a CNS drug will be at the right place, at the right time and at the right concentration
  • be able to compare and choose between different methods for studying parameters that can be used to understand or predict BBB transport and CNS distribution

Program


 

Day 1

Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles

09.00 – 09.30 Welcome and Introduction
09.30 – 10.00 BBB Morphology, Anatomy, Physiology and Function
10.00 – 10.30 Coffee and Tea
10.30 – 11.30 BBB Transport Modes
11.30 – 12.30 Larger Molecules and Approaches to Overcome Problems in CNS Drug Delivery
12.30 – 13.30 Lunch
13.30 – 14.30 General Pharmacokinetic (PK) Principles
14.30 – 15.30 BBB transport: Rate and Extent. Impact on Brain vs Plasma PK
15.30 – 16.00 Coffee and Tea
16.00 – 16.45 Factors in CNS Drug Effects
16.45 – 17.30 Discussions BBB Research Issues from Participants
18.00 – 20.00 Drinks and Dinner at Course Hotel

Day 2

Principles and Methods for Investigating BBB Transport 

09.00 – 09.30 In Vitro Methods (Cell Cultures, Monolayers)
09.30 – 10.00 In Situ Methods (Brain Sampling Techniques)
10.00 – 10.30 Coffee and Tea
10.30 – 11.30 In Vivo Monitoring Methods: CSF & Microdialysis
11.30 – 12.00 In Vivo Monitoring Methods: PET
12.00 – 13.00 Lunch
13.00 – 13.45 Sources of Variability in CNS Drug Distribution
13.45 – 14.45 In Vitro Methods (Brain Slice and – Homogenate Uptake)
14.45 – 15.15 Coffee and tea
15.15 – 15.45 Factors that Influence Unbound Brain Pharmacokinetics
15.45 – 17.15 Hands-on Computer Exercise and Discussion: Plasma and Brain PK Relationships
18.00 – 21.30 Drinks and Dinner downtown Leiden

Day 3

Integration and Translation of CNS Drug Delivery Principles

09.00 – 10.00 Translational PK/PD Relationships of CNS Active Drugs
10.00 – 10.30 Coffee and Tea
10.30 – 11.30 What Parameters to Use in CNS Drug Development?
11.30 – 13.00 Hands-on Assignment on BBB Transport and Intracellular Distribution
13.00 – 14.00 Lunch
14.00 – 14.30 Discussion on Hands-on Assignment
14.15 – 14.45 Concluding Discussions and Perspectives
14.45 – 15.15 Certificates and Final Comments

Location


Clarion Hotel Gillet

The course will take place at Clarion Hotel Gillet, Dragarbrunnsgatan 23, 75320 Uppsala, Sweden, phone +46 18 681800, email cl.uppsala@choice.se. Web page, please search Google.

Hotel Leiden

Hotel Gillet is a four star hotel located in the center of Uppsala, within 10 min walking distance from the central train station, or 30 min with taxi from Stockholm International Airport.

Hotel Leiden

 

 

 

 


Team


 

The course is a coproduction of In Focus and Udenaes Consulting:

Margareta Hammarlund-Udenaes
Udenaes Consulting

Elizabeth de Lange
In Focus

 

Margareta Hammarlund-Udenaes is a Professor in Pharmacokinetics and Pharmacodynamics at Uppsala University, head of the Translational PKPD Group, and Dean of the Faculty of Pharmacy in Uppsala. Her research is focused at studying pharmacokinetic aspects of BBB transport of drugs in relation to CNS effects, which has led to the development of new concepts within the BBB transport area, focusing on unbound drug relationships. The concepts make it possible to study the BBB contribution to drug transport to the CNS. A method frequently used is microdialysis, but also PET and other techniques are utilized. Her research group has also optimized in vitro methods for more rapid screening of BBB transport properties in drug discovery. They also study nanodelivery to the brain. Dr Hammarlund-Udenaes is an Associate Editor of Pharmaceutical Research and a member of the Editorial Advisory Board of Journal of Pharmaceutical Sciences and Fluids and Barriers of the Central Nervous System (FBCNS). She became an AAPS Fellow in 2005 and is a frequent lecturer at conferences and in drug industry within the BBB transport – pharmacokinetics area. She co-founded and has co-chaired several of the International Symposia on Microdialysis in Drug Research and Development together with Dr de Lange. She was the Chair of the Gordon Conference on Barriers of the CNS in 2014. Her company Udenaes Consulting (udenaesconsulting@gmail.com) gives advice to drug industry in PKPD and BBB transport issues.

Elizabeth de Lange is heading the Quantitative and Translational Pharmacology Research Group at the Research Division of Systems Biomedicine and Pharmacology at the Leiden Academic Centre of Drug Research. She obtained her PhD on The Use of Microdialysis to Study BBB Transport Characteristics of Drugs. Her group’s research involves the identification and characterization of the context dependency of the rate and extent of key factors in the dose-response relationship of CNS drugs in health and CNS disorders, with the ultimate aim being to aid in the prediction CNS drug effects in the clinical setting (translational research). As a highlight, recently a comprehensive CNS physiology-based pharmacokinetic model has been developed that is able to adequately predict drug concentration profiles in multiple CNS compartments in human. She co-founded and has co-chaired several of the International Symposia on Microdialysis in Drug Research and Development together with Dr Hammarlund-Udenaes, and organized many other scientific events among which the 2014 Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS). She is an AAPS Fellow since 2013. She is a frequently invited lecturer. Her company In Focus provides courses, training and gives advice on pharmacokinetics, BBB transport, (CNS) target site distribution, binding  kinetics and effects (PKPD) (info@infocus-ecmdelange.nl).

 


Registration


Fee

The course fee includes course attendance, course material, lunches, dinners, coffee/tea at start and during breaks. It does not include accommodation.

Payment completed before July 1st 2019:

PhD students* € 1495,- (excl. VAT)
Academic € 1695,- (excl. VAT)
Business € 1895,- (excl. VAT)

Payment completed before September 1st 2019:

PhD students* € 1795,- (excl. VAT)
Academic € 1995,- (excl. VAT)
Business € 2295,- (excl. VAT)

For participants based in Sweden, please add VAT 25 %. Participants outside of Sweden do not need to pay VAT.

*PhD students should accompany this form by a letter of their supervisor to ensure the status of PhD student.

Registration Form

Please register via the digital registration form at:

http://www.bbbcourses.org/registration/

A specified invoice can be made upon request. Registration is complete upon receiving the payment. A confirmation of payment and therewith registration will be sent by email.

Payment information

Udenaes Consulting
SEB (106 40 Stockholm, Sweden)
IBAN Account SE3850000000053681044384
BIC: ESSESESS

Company Information

Udenaes Consulting
Bruksvagen 29
752 41 Uppsala, Sweden
+46 70 5301 147
udenaesconsulting@gmail.com
VAT: SE530124754901

Cancellation policy

In case of cancellation before July 31st 2019 payment will be restituted (-10% administration costs).
At any time, the participant may be exchanged for another participant.

 

Details

Start:
October 2
End:
October 4

Venue

Uppsala Konsert & Kongress
Vaksala torg 1
Uppsala, 753 31 Sweden